- Beato Miguel Rúa, (1837 - 1910) Rector Mayor de 1888 a 1910
- Pablo Albera, (1844 - 1921) Rector Mayor de 1910 a 1921
- Beato Felipe Rinaldi, (1856 - 1931) Rector Mayor de 1922 a 1931
- Pedro Ricaldone, (1870 - 1951) Rector Mayor de 1932 a 1951
- Renato Ziggiotti, (1892 - 1983) Rector Mayor de 1952 a 1965
- Luis Ricceri, (1901 - 1989) Rector Mayor de 1965 a 1977
- Egidio Viganò, (1920 - 1995) Rector Mayor de 1977 a 1995
- Juan Edmundo Vecchi, (1931 - 2002) Rector Mayor de 1995 a 2002
- Pascual Chávez (mexicano), (1942 - ) Rector Mayor desde 2002-reconfirmado (2008 - 2014)
pagina de don bosco en mi sena:
http://sites.google.com/a/misena.edu.co/salesianospopayan15/